efime Berberine x 60 capsules

berberine can reduce IGF-1 levels. Berberine has been shown to decrease intestinal IGF-1, IGFBP-3 levels, and IGF-1R expression in diabetic mice. Additionally, berberine can inhibit intestinal GLUT2 translocation, which is involved in glucose absorption, potentially through the IGF-1R-PLC-β2-GLUT2 signaling pathway. 
Here's a more detailed explanation:
IGF-1 and its role:
Insulin-like growth factor 1 (IGF-1) is a hormone that plays a crucial role in regulating growth, metabolism, and other bodily functions. It also has a potential link to the development of certain chronic diseases, such as type 2 diabetes and obesity. 
Berberine's effects on IGF-1:
Studies have shown that berberine can reduce intestinal IGF-1 levels and the expression of its receptor (IGF-1R) in diabetic mice. This suggests that berberine may modulate the IGF-1 signaling pathway, which could have beneficial effects on glucose metabolism and other related processes. 
Mechanism of action:
One potential mechanism by which berberine reduces IGF-1 levels is through its ability to inhibit intestinal GLUT2 translocation. GLUT2 is a glucose transporter protein that facilitates the movement of glucose into cells. By inhibiting GLUT2 translocation, berberine may reduce glucose absorption in the intestine, potentially impacting IGF-1 levels and glucose metabolism. 
Potential benefits:
The reduction of IGF-1 levels by berberine may have several potential benefits, including improved glucose control, enhanced insulin sensitivity, and reduced risk of certain metabolic disorders, as suggested by several studies (2, 3, 4, 5). 

• The composition of the dietary supplement efime Berberine includes high-quality barberry root extract standardized to 95% berberine content. Supplementing the daily diet with this ingredient is recommended as support for glucose metabolism.

Efime Berberine Ingredients:

Barberry root extract (Berberis aristata) standardized to 95% berberine, capsule shell: HPMC (organic cellulose derivative), anti-caking agent: VEGESIL® – silicon dioxide of plant origin (from rice).

Ingredients in two capsules (recommended daily dose):barberry root extract (Berberis aristata) standardized to 95% berberine content – 500mg, including: berberine – 475mg.

Efime Berberine action:

The dietary supplement efime Berberine is intended to be used as a supplement to the daily diet with berberine. This ingredient supports the control of blood glucose levels. The source of berberine contained in the preparation is a standardized extract of barberry root. The recommended daily dose, i.e. two capsules, provides as much as 475 mg of berberine.

Application:
Efime Berberine dietary supplement intended for use to supplement the daily diet with barberry root extract.

Additional information:
A dietary supplement cannot be used as a substitute, i.e. a replacement for a varied diet. Maintaining a balanced diet and a healthy lifestyle is of great importance. Store the product out of reach of children, at room temperature. It is recommended to protect from moisture and light. The possibility of use during pregnancy and breastfeeding should be discussed with a doctor by women.

Contraindications:
Do not use in case of hypersensitivity to any of the ingredients of the dietary supplement.

How to use efime Berberine capsules:

Recommended daily dose: two capsules. Use with a meal. Do not exceed the recommended daily dose.