• 500 mg sodium bicarbonate

• wax, yellow
• Soybean oil, hydrogenated
• Soybean oil, partially hydrogenated
• Lecithin (soybean)
• Rapeseed oil, refined
• Iron(II,III) oxide
• titanium dioxide
• Glycerol 85%
• gelatin
• sorbitol
• sorbitan
• mannitol
• polyols
• hypromellose
• hyprolose
• talc
• macrogol
• Methacrylic acid ethyl acrylate copolymer (1:1)
• Polysorbate 80
• Sodium Lauryl Sulfate
• propylene glycol
• glycerol monostearate
• Hydrochloric acid for pH adjustment
• water, purified
• 137 mg sodium ion

NEPHROTRANS, sodium hydrogen carbonate, metabolic acidosis, sodium bicarbonate indication

• The preparation is an acidosis therapeutic for the correction of metabolic acidosis.
• application areas
  • For the treatment of metabolically-caused hyperacidity of the blood (metabolic acidosis) and for maintenance treatment against recurrence of metabolically-caused hyperacidity of the blood in the case of chronic underperformance of the kidneys (chronic renal insufficiency).
• Note: Patients with a blood pH below 7.2 require correction of hyperacidity (acidosis) by infusion.

NEPHROTRANS, sodium hydrogen carbonate, metabolic acidosis, sodium bicarbonate dosage

• Always take the medicine exactly as directed. Please check with your doctor or pharmacist if you are not sure.
• The dosage always depends on the severity of the metabolic acidification of the blood (metabolic acidosis).
• Unless otherwise prescribed by the doctor, the usual dose is:
  • 6 - 9 soft capsules per day, corresponding to 3 - 4.5 g sodium bicarbonate per day.

• duration of use
  • As long as an existing metabolic acidosis requires a prescription of Nephrotrans by a doctor. The preparation must not be taken uncontrolled over a longer period of time.
  • Please talk to your doctor or pharmacist if you have the impression that the effect of the medicine is too strong or too weak.

• If you take more than you should
  • Overdose of sodium bicarbonate can lead to alkalosis of the blood with symptoms such as muscle weakness, exhaustion, shallow breathing. Please contact your doctor immediately to initiate countermeasures and dose adjustment.

• If you forget to take a dose
  • Do not take a double dose to make up for a forgotten dose, in this case continue with the prescribed dose. However, please inform your doctor about this.

• If you stop taking it
  • Please inform your doctor about this.

• If you have any further questions on the use of the medicine, ask your doctor or pharmacist.

NEPHROTRANS, sodium hydrogen carbonate, metabolic acidosis, sodium bicarbonate way

• The soft capsules should be taken unchewed, possibly with a little liquid throughout the day with meals.

side effects

• Like all medicines, the preparation can have side effects, although not everyone gets them.
• The frequency of side effects is based on the following categories:
  • Very common: affects more than 1 in 10 people
  • Common: affects 1 to 10 users in 100
  • Uncommon: affects 1 to 10 users in 1,000
  • Rare: affects 1 to 10 users in 10,000
  • Very rare: affects less than 1 in 10,000 people
  • Not known: frequency cannot be estimated from the available data.
• possible side effects
  • Gastrointestinal symptoms such as bloating and abdominal pain may occur.
  • Prolonged use of the drug can promote the formation of calcium or magnesium phosphate stones in the kidneys.
  • If the dose is exceeded, muscular hyperexcitability due to reduced calcium (hypocalcaemic tetany) is possible. In the case of pre-existing disorders of the gastrointestinal tract, such as diarrhea, these disorders may be aggravated.
• Please tell your doctor or pharmacist if any of the side effects gets serious, or if you notice any side effects that are not listed.

NEPHROTRANS, sodium hydrogen carbonate, metabolic acidosis, sodium bicarbonate interactions

• When taking the preparation with other medicines
  • Please inform your doctor or pharmacist if you are taking/using or have recently taken/used other medicines, even if they are non-prescription medicines.
  • The absorption and excretion of weak acids and bases can be influenced by increasing the pH value in the stomach and intestines. This applies, for example, to sympathomimetics, anticholinergics, tricyclic antidepressants, barbiturates, H2 antagonists, captopril, quinidine.
  • Functional interactions are possible with gluco- and mineralocorticoids, androgens and diuretics that increase potassium excretion. Attention must be paid to a possible influence on the solubility of drugs that are eliminated with the urine (eg ciprofloxacin).
• Taking the drug with food and drink
  • No food and drink interaction studies have been performed.

Contraindications

• The medicine must not be taken
  • if you are allergic (hypersensitive) to sodium bicarbonate or any of the other ingredients of the preparation.
  • in the case of a metabolic base excess (metabolic alkalosis).
  • with reduced serum potassium (hypokalemia).
  • with increased serum sodium (hypernatraemia).
  • on a low-sodium diet.
  • by children under the age of 14.

pregnancy and breast feeding period

• Ask your doctor or pharmacist for advice before taking/using any medicine.
• There is no experience with taking the preparation. Although there are no objections to the use of sodium bicarbonate (the active ingredient in the preparation) if indicated, the drug should only be taken during pregnancy and breastfeeding after consultation with the doctor treating you.

patient NEPHROTRANS, sodium hydrogen carbonate, metabolic acidosis, sodium bicarbonate notes

• Special care is required when taking the drug
  • with weakened breathing (hypoventilation).
  • if you have low levels of calcium in your blood (hypocalcaemia).
  • with increased salt content of the blood (hyperosmolar conditions).
• The sodium content (137 mg sodium = 6 mEq per soft capsule) should be taken into account, especially in long-term treatment; if necessary, a low-salt or strictly low-salt diet should be observed in order to counteract the further increase in existing high blood pressure.
• The effect of the drug should be checked at least 1-2 weeks apart (e.g. pH measurement, standard bicarbonate, alkali reserve) initially and especially with higher doses. The plasma electrolytes, especially sodium, potassium and calcium, must also be checked regularly. Depending on the result of these checks, the respective further dosage is to be determined. These checks must also be carried out regularly under long-term medication. Depending on the result of these checks, the respective further dosage is to be determined. Any overbasing can be corrected by reducing the dose.

• Driving and using machines:
  • The preparation has no influence on the ability to drive and use machines.