Used to treat pre eclampsia, eclampsia, preterm labor tendencies and severe magnesium deficiency

Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium ingredients

water for injections
Sulfuric acid for pH adjustment

Indication Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

The drug is a mineral supplement.
In preeclampsia, eclampsia, tendencies towards premature birth, severe magnesium deficiency (normal values of magnesium in the serum 0.8 - 1.1 mmol/l).

Dosage Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium:

Always use the medicine exactly as described or as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are not sure.
The dosage depends on the indication and on the magnesium serum level.
- The recommended dosage is
  - For preeclampsia, eclampsia: 4 - 6 g magnesium sulfate (16 - 24 mmol magnesium) iv in diluted form using a perfusor or short infusion over 15 - 20 minutes.
  - Maintenance dose 1 - 2 g magnesium sulfate / hour (4 - 8 mmol magnesium / hour) up to 24 - 48 hours postpartum.
  - If you are trying to give birth early, as an additional therapy to tocolysis with betamimetics: 4 - 8 mmol magnesium / hour.
  - For severe magnesium deficiency: 20 mmol magnesium / day.

If you use more than you should:
- The main symptoms and general signs of overdose are muscle weakness, disappearance of deep tendon reflexes, drop in blood pressure and heart rate, increase in skin blood flow, ECG changes, vomiting, sedation and confusion.
- If the plasma magnesium concentration exceeds 2 mmol/l, the deep tendon reflexes are weakened, at around 5 mmol/l they are no longer present and respiratory depression occurs. Coma occurs at 6.0 - 7.5 mmol/l and respiratory paralysis and diastolic cardiac arrest from 8 mmol/l.
- Magnesium intoxication should be treated with intravenous calcium supply - as an antidote - (e.g. slow iv administration of 10 ml of a 10% calcium gluconate solution). In addition, the cholinesterase blocker neostigmine should be administered because it increases acetylcholine concentration and antagonizes the muscle relaxant effect of magnesium.

If you forgot the application
- Do not apply twice if you forget the previous application.

way Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

The concentrate for infusion should be diluted and then infused intravenously.
Suitable dilution solutions are e.g. B.: 5% glucose and 0.9% sodium chloride solution.
As an adjunctive therapy to tocolysis with betamimetics, 0.9% sodium chloride solution should be used as a dilution solution instead of the 5% glucose solution because of the hyperglycaemic effect of the tocolytics.
The ready-to-use solution for infusion should be used immediately after dilution.
Because of possible precipitation, parenteral magnesium sulphate administrations should not be mixed with solutions containing calcium, phosphate, tetracycline or alcohol.
In attempts to give birth prematurely, as adjunctive therapy to tocolysis with betamimetics:
- To prepare the infusion solution z. B. Mix 2 ampoules with 480 ml diluent.
For severe magnesium deficiency:
- To prepare the infusion solution z. B. Mix 1 ampoule with 990 ml dilution solution.
The dosage depends on the area of application or the magnesium serum level.

Side effects :

Like all medicines, this medicine can cause side effects, although not everybody gets them.
When given intravenously, there is generally a meaningless feeling of warmth and flushing (reddening of the skin). If magnesium sulfate is administered parenterally too quickly, temporary side effects in the form of nausea, headaches, tingling, sweating, agitation, restlessness, drowsiness and slowing of heart and breathing activity may occur, particularly in vasolatile patients.
In addition, parenteral administration of magnesium can lead to bradycardia, conduction disorders and peripheral vasodilatation.
Dose reduction or discontinuation of the preparation generally lead to a rapid disappearance of these side effects.
If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects that are not specified.

Interactions Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

Use with other medicines:
- Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
- Diuretics, aminoglycoside antibiotics (such as gentamycin, tobramycin, amphotericin B), immunosuppressants (such as cyclosporine A), cytostatics (such as cisplatin), and digitalis glycosides cause increased excretion of magnesium through the kidneys.
- The following drugs should not be given at the same time:
  - Curare-type muscle relaxants - these enhance the action of magnesium at the motor endplate;
  - Barbiturates, narcotics, or other hypnotics - these increase the risk of respiratory depression;
  - Calcium salts - these reduce the effects of magnesium.
- The simultaneous administration of magnesium and calcium antagonists may only take place under intensive care conditions, as it can lead to an increase in the blood pressure-lowering effects.

Contraindications :

The drug must not be used
- if you are allergic to magnesium sulfate or any of the other ingredients of this medicine.
- with pronounced bradycardia (slow heart activity),
- in myasthenia gravis (muscle weakness)
- with AV block (interruption of the conduction system in the heart)
- with a tendency to infection stones (calcium magnesium ammonium phosphate stones).

Pregnancy and lactation :

There is no evidence of a malformation risk. However, the documented human experience of use in early pregnancy is very limited. The medicinal product should therefore only be used after an appropriate benefit-risk assessment by the attending physician.
If magnesium is administered parenterally shortly before birth, the neonate should be monitored for signs of toxicity (neurological depression with respiratory depression, muscle weakness, loss of reflexes) during the first 24-48 hours of life. The administration of aminoglycoside antibiotics should be avoided during this period as there are indications of interactions.
Disorders of skeletal ossification in neonates have been reported with long-term parenteral use of magnesium to inhibit labor in high doses. However, when used in the specified therapeutic dosage, there are no concerns in this regard.

Patient Notes :

Warnings and Precautions
- Please talk to your doctor or pharmacist before using the preparation.
- Particular caution is required when using
  - For severe renal excretion disorders. A dose adjustment to the degree of the elimination disorder is necessary.
  - The following monitoring and precautionary measures should be taken during high-dose parenteral magnesium therapy:
    - Monitoring of cardiovascular and respiratory function (respiratory rate not less than 16/min),
    - Examination of the triggerability of the patellar tendon reflexes,
    - Determination of urine output (not less than 25 ml/h),
    - Provision of ampoules of calcium gluconate, 10% as an antidote
    - Guaranteeing intensive medical measures if the antidote alone is not sufficient.
- Because of possible precipitation, the medicinal product should not be mixed with solutions containing calcium, phosphate, tetracycline or alcohol.
- children and young people
  - No data is available.

Driving and using machines:
- When used as intended, no special precautions are required.

Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium Verla®

Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium Verla®

Magnesium Verla® iv 20mmol/10ml

active Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium ingredients

Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium ingredients

Indication Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

Dosage Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium:

way Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

Side effects :

Interactions Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium :

Contraindications :

Pregnancy and lactation :

Patient Notes :

Description

Treat pre eclampsia, eclampsia, pre-eclampsia, Magnesium Verla®