Folic acid forte Hevert ampoules folic acid deficiency

• 20 mg folic acid

• Sodium chloride
• Sodium hydroxide for pH adjustment
• Water for injections

Vitamin preparation for folic acid deficiency.

Composition:
1 ampoule of 2 ml contains: folic acid 20 mg.
Excipients: sodium chloride, sodium hydroxide, water for injections.

Areas of application:
Therapy of folic acid deficiency, for example in dialysis patients, when oral folic acid substitution is not possible and when the standard dosage cannot be sufficiently effective.

Folic acid deficiency Dosage:

Unless otherwise prescribed, inject half to 1 ampoule intramuscularly or intravenously 1 to 3 times a week.

Contraindications:
Folic acid must not be used in megaloblastic anemia due to isolated vitamin B12 deficiency. In megaloblastic anemia of unknown cause, it should be checked whether there is a folic acid deficiency before starting treatment.

Pregnancy and breastfeeding:
There are no known risks for doses of up to 5 mg folic acid per day. Folic acid should not be used in higher doses during pregnancy and breastfeeding.

Side effects:
In rare individual cases, allergic reactions with itching, skin rash, difficulty breathing and shock can occur. After high doses, the tendency to cramp may increase with additional therapy with anti-epileptic drugs. Furthermore, gastrointestinal disorders, nightmares, excitement and depression have been observed in rare cases after high doses.

Folic acid deficiency Interactions:

Folic acid must not be given at the same time as folic acid antagonists, but only afterwards.

Even in the case of life-threatening megaloblastic anemia, the diagnosis of a possible vitamin B12 deficiency must be ruled out before starting therapy because of the risk of irreversible neurological disorders. Since folic acid and vitamin B12 cause an increase in reticulocytes in the blood, the administration of one of the two vitamins can mask the deficiency of the other vitamin under certain circumstances.

Increase in the tendency to cramp under anticonvulsant therapy, especially when using high doses to treat poisoning with folic acid antagonists.

Folic acid deficiency can be remedied quickly and effectively with »Folic Acid forte-Hevert« solution for injection.

Folic acid belongs to the group of B vitamins and is involved as a cofactor in many metabolic processes, especially in protein and nucleic acid metabolism. Folic acid is found in metabolically active tissues in the body such as the liver, bone marrow and nerves, but also in the muscles.

Meeting the folate requirement is difficult because a considerable proportion of the food folate is destroyed during cooking by the influence of heat and oxygen or, due to its solubility in water, is transferred to the washing or cooking water and is discarded. In individual cases, folate losses due to kitchen preparation can be up to 100%. Insufficient intake of folic acid leads to symptoms of folic acid deficiency caused by an unbalanced diet, e.g. with increased alcohol consumption or insufficient absorption due to rapid gastrointestinal passage (diarrheal diseases), or after resection of the upper small intestine or increased consumption, e.g. during dialysis Overactive thyroid gland during pregnancy or reduced utilization due to liver diseases and antagonistic effects of drugs, e.g. various antibiotics,

During pregnancy, large amounts of folate are needed to supply the embryo with folate, for the formation of placental tissue and to replace the increased renal loss of folate (affecting the kidneys). The folate requirement of pregnant women is therefore doubled compared to the normal female population. The folate requirement of breastfeeding mothers is also essentially increased due to the release of folic acid in the milk.

Folic acid deficiency symptoms are expressed in neurological (nervous) and psychiatric disorders (organic brain syndrome, disruption of the pyramidal tracts, neuropathies) with general weakness, insomnia, forgetfulness, paresthesia and tingling, as well as pale complexion, painful, swollen and shiny tongue.

Other symptoms of folic acid deficiency are changes in the mucous membrane in the oral cavity and gastrointestinal disorders that lead to diarrhea. Folic acid must therefore be supplied to the organism in high doses.
Advanced folic acid deficiency is always expressed by changes in the red blood count (macrocytic anemia). The disorders are particularly pronounced when folic acid and vitamin B 12 deficiencies coincide. In this case, the combination treatment with »Vitamin B12-Hevert plus Folic Acid-Hevert« solution for injection is recommended.

Folic acid deficiency

Notes:
"Folic acid forte-Hevert" ampoules can also be used as drinking ampoules if required.
"Folic acid Hevert" tablets (5 mg folic acid per tablet) are used for long-term oral therapy.