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CALCIUMFOLINATE GRY 15 tablets
Calciumfolinat-GRY® 15 mg belongs to the drug group of antidotes (substance that counteracts the toxicity of cytostatic treatment). Calciumfolinat-GRY® 15 mg is also used in combination with 5-fluorouracil in the treatment of colon cancer. Finally, Calciumfolinat-GRY® 15 mg can be taken to treat folic acid deficiencies.
Calciumfolinat-GRY® 15 mg is used
- for calcium folinate rescue in methotrexate therapy
a) to prevent symptoms of intoxication from (medium) high-dose methotrexate therapy or persistently high methotrexate serum levels (also in the case of low-dose methotrexate therapies).
Note:
Persistently high methotrexate serum levels are to be expected in particular in the case of pleural effusions, ascites, renal insufficiency and insufficient fluid intake during methotrexate therapy.
b) for the treatment of symptoms of intoxication from methotrexate therapy that can be attributed to a tetrahydrofolic acid deficiency.
- for the treatment of folic acid deficiencies of various origins that cannot be remedied by dietary measures.
Hints:
a) With this treatment, a vitamin B12 deficiency should be excluded in the differential diagnosis.
b) In contrast to the first two areas of application mentioned, the use of folic acid is sufficient here.
- in combination with 5-fluorouracil to treat advanced cancer of the rectum
Composition:
The active substance is: calcium folinate 5H2O 19.1 mg (equivalent to 15 mg folinic acid); The other ingredients are:
lactose monohydrate, corn starch, magnesium stearate (Ph. Eur.), pregelatinized starch.
Application:
Storage:
Manufacturer data:
TEVA Pharma BV
POBox 43011, 3540 AA Utrecht